Narasimhan K, Lin SL, Tong T, Baig S, Ho S, Sukumar P, Biswas A, Hahn S, Bajic VB, Choolani M (2013) Maternal Serum Protein Profile and Immune Response Protein Subunits as Markers for Non-Invasive Prenatal Diagnosis of Trisomy 21, 18, and 13
Dietary interventions have been evaluated as complementary or alternative treatments in other chronic inflammatory disorders
People with MTHFS variants cannot do this efficientlyfolinic acid builds up instead of being metabolized. In a landmark 2018 study, treating MTHFS-deficient patients with folinic acid caused it to accumulate 30-fold and actually worsened their cerebral folate deficiency
10.1038/srep42394 82 HetzC
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